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This feedback promotes microglial activation, enhances pain sensitivity, and contributes to emotional disturbances, leading to a state of visceral hypersensitivity

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A study reported that the levels of antioxidants in seminal plasma from infertile men were significantly lower than levels in fertile controls, and it was demonstrated that the levels of ROS produced by spermatozoa were negatively correlated with the quality of sperm in the original semen (Pasqualotto et al., 2000)

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The fitness-as-medicine model is going mainstream